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Solid-state nuclear magnetic resonance spectroscopy—pharmaceutical applications

✍ Scribed by Patrick A. Tishmack; David E. Bugay; Stephen R. Byrn

Publisher
John Wiley and Sons
Year
2003
Tongue
English
Weight
374 KB
Volume
92
Category
Article
ISSN
0022-3549

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✦ Synopsis

Solid-state nuclear magnetic resonance (NMR) spectroscopy has become an integral technique in the field of pharmaceutical sciences. This review focuses on the use of solid-state NMR techniques for the characterization of pharmaceutical solids (drug substance and dosage form). These techniques include methods for (1) studying structure and conformation, (2) analyzing molecular motions (relaxation and exchange spectroscopy), (3) assigning resonances (spectral editing and two-dimensional correlation spectroscopy), and (4) measuring internuclear distances.

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