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Solid-state characterization of a novel chemotherapeutic drug

โœ Scribed by A. Marini; V. Berbenni; G. Bruni; A. Maggioni; P. Cofrancesco; C. Sinistri; A. Orlandi; M. Villa

Publisher
John Wiley and Sons
Year
2003
Tongue
English
Weight
311 KB
Volume
92
Category
Article
ISSN
0022-3549

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โœฆ Synopsis

We present the results of a thermal, spectroscopic, diffractometric, and microscopic study of a novel DNA intercalator synthesized by Novuspharma S.p.A. (code name BRR 2778, purity by high-performance liquid chromatography: 99.4%). We found that the form that is stable at room temperature contains 1.5 water molecules per unit of formula (or about 4.7% in mass): this water is reversibly lost in two stages below 80 degrees and 90 degrees C in dry and wet nitrogen atmosphere, respectively. The hydrated compound is a pseudo-polymorph and dehydration is accompanied by a structural change that modifies the diffraction pattern without changing the shape of the microcrystals. Annealing above 150 degrees C causes decomposition of the anhydrous form and (above 190 degrees C) amorphization of the solid residue occurs.

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