Solid phase synthesis of the 3′-terminal nonadecaribonucleoside octadecaphosphate sequence of yeast alanine transfer ribonucleic acid

✍ Scribed by T.Sudhakar Rao; Colin B. Reese; Halina T. Serafinowska; Hiroshi Takaku; Giovanni Zappia

• Book ID: 104227949
• Publisher: Elsevier Science
• Year: 1987
• Tongue: French
• Weight: 386 KB
• Volume: 28
• Category: Article
• ISSN: 0040-4039
• DOI: 10.1016/s0040-4039(00)96655-3

✦ Synopsis

The rapid synthesis of the 3'-terminal decaribonucleoside nonaphosphate and nonadecaribonucleoside octadecaphosphate sequences of yeast tRNAAla by the phosphoramidite approach on controlled pore glass is described; the synthetic products were found to be identical to the authentic oligoribonucleotides, prepared by the phosphotriester approach in solution.

Considerable progress has been made in recent years in the rapid chemical synthesis of oligo-and poly-deoxyribonucleotides (i.e. DNA sequences) on solid supportsl. Progress has