Solid-phase synthesis of substituted quinoline and isoquinoline derivatives using heterocyclic N-oxide chemistry
β Scribed by Michael Z. Hoemann; Anita Melikian-Badalian; G. Kumaravel; James R. Hauske
- Book ID
- 108386867
- Publisher
- Elsevier Science
- Year
- 1998
- Tongue
- French
- Weight
- 187 KB
- Volume
- 39
- Category
- Article
- ISSN
- 0040-4039
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## Abstract magnified image A oneβpot procedure for the synthesis of pyrrolo[2,1β__a__]isoquinolines and pyrrolo[1,2β__a__]quinolines in good to excellent yields has been reported, using quinoline or isoquinoline, phenacylbromide derivatives and activated alkynes in aqueous medium. J. Heterocyclic
## Abstract magnified image A series of new highly substituted isoquinoline derivatives was obtained from the reaction of 2β(1βsubstituted piperidinβ4βylidene)malononitrile, benzaldehyde and malononitrile or cyanoacetate in ionic liquid at 50Β°C. This novel procedure was different from the previous