Solid phase synthesis of substituted coumarin-3-carboxylic acids via the Knoevenagel condensation
โ Scribed by Brett T Watson; Gerda E Christiansen
- Book ID
- 108386947
- Publisher
- Elsevier Science
- Year
- 1998
- Tongue
- French
- Weight
- 177 KB
- Volume
- 39
- Category
- Article
- ISSN
- 0040-4039
No coin nor oath required. For personal study only.
๐ SIMILAR VOLUMES
Coumarin-3-carboxylic acids were obtained in high yields with excellent purity from ortho-hydroxybenzaldehydes and Meldrum's acid after a 2 h reflux in ethanol. The less reactive ketones were first reacted with alcoholic ammonia to form ketimines, which were then condensed with Meldrum's acid to gen
## Abstract __L__โProline was utilized as an efficient organoโcatalyst for the environmentally benign synthesis of 3โsubstituted coumarins by the Knoevenagel condensation of substituted 2โhydroxybenzaldehydes with reactive methylene compounds under solvent free conditions.