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Solid Phase Synthesis of Macrocycles by an Intramolecular Ketophosphonate Reaction. Synthesis of a ( dl )-Muscone Library

✍ Scribed by Nicolaou, K. C.; Pastor, Joaquín; Winssinger, Nicolas; Murphy, Fiona


Book ID
120237503
Publisher
American Chemical Society
Year
1998
Tongue
English
Weight
47 KB
Volume
120
Category
Article
ISSN
0002-7863

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A novel route for the synthesis of tetrahydropyrazine-2-ones on solid support through intramolecular Mitsunobu reactions is reported. The syntheses employ reductive amination of commercially available amino alcohols to attach them to ArgoGeI-MB-CHO resin. Amino acids are then coupled to the derivati