✦ LIBER ✦

Solid-phase synthesis of lysine-based cluster galactosides with high affinity for the asialoglycoprotein Receptor

✍ Scribed by A.Rob P.M. Valentijn; Gijgs A. van der Marel; Leo A.J.M. Sliedregt; Theo J.C. van Berkel; Erik A.L. Biessen; Jacques H. van Boom

Publisher: Elsevier Science
Year: 1997
Tongue: French
Weight: 855 KB
Volume: 53
Category: Article
ISSN: 0040-4020
DOI: 10.1016/s0040-4020(96)01018-6

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✦ Synopsis

Structurally well defined di-and tri-antennary lysine-based galactose-and N-acetylgalactosaminecontaining ligands for the hepatic asialoglycoprotein receptor (ASGP-R) could be assembled on a solid support. using a combined Fmoc/Alloc protecting group strategy for the amino functions of lysine. This methodology allowed easy introduction of spacers, the length of which could be readily accommodated for optimal binding to the ASGP-R.