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Solid-Phase Synthesis of Lipidated Ras Peptides Employing the Ellman Sulfonamide Linker

✍ Scribed by Gemma Triola; Marc Gerauer; Kristina Görmer; Lucas Brunsveld; Herbert Waldmann


Publisher
John Wiley and Sons
Year
2010
Tongue
English
Weight
455 KB
Volume
16
Category
Article
ISSN
0947-6539

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A new aminoethyl-polystyrene linker, stable at low concentrations of TFA, has been developed for the solid phase synthesis of peptide amides. The described linker is stable under conditions which remove Bu(t) protecting groups (30-50% TFA in DCM) and the desired product can be finally cleaved off th