It has been known that co-administration of morphine with either cholecystokinin (CCK) receptor or melanocortin (MC) receptor antagonists enhance morphine's analgesic efficacy by reducing serious side effects such as tolerance and addiction. Considering these synergistic effects, we have designed t
β¦ LIBER β¦
Solid-Phase Synthesis of Heterobivalent Ligands Targeted to Melanocortin and Cholecystokinin Receptors
β Scribed by Jatinder S. Josan; Josef Vagner; Heather L. Handl; Rajesh Sankaranarayanan; Robert J. Gillies; Victor J. Hruby
- Publisher
- Springer Netherlands
- Year
- 2008
- Tongue
- English
- Weight
- 317 KB
- Volume
- 14
- Category
- Article
- ISSN
- 1573-3149
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## Abstract Two novel solidβphase organic tagging (SPOrT) resins were synthesized to facilitate the labeling of peptides and small organic compounds with a fluorescent probe. Both resins were obtained from the commercially available backbone amide linker (BAL) resin. Following the solidβphase synth