Solid-phase synthesis of dual α4β1/α4β7 integrin antagonists: two scaffolds with overlapping pharmacophores
✍ Scribed by Georgette M. Castanedo; Fredrick C. Sailes; Nathan J.P. Dubree; John B. Nicholas; Lisa Caris; Kevin Clark; Susan M. Keating; Maureen H. Beresini; Henry Chiu; Sherman Fong; James C. Marsters Jr.; David Y. Jackson; Daniel P. Sutherlin
- Book ID
- 108477300
- Publisher
- Elsevier Science
- Year
- 2002
- Tongue
- English
- Weight
- 414 KB
- Volume
- 12
- Category
- Article
- ISSN
- 0960-894X
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The tuning of protein ± protein interactions by small nonpeptidic molecules remains one of the great challenges in medicinal chemistry. Although already proposed in 1980 by Farmer, [1] only a few successful examples on the synthesis of peptidomimetics based on rigid scaffolds such as cyclohexane and
The tuning of protein ± protein interactions by small nonpeptidic molecules remains one of the great challenges in medicinal chemistry. Although already proposed in 1980 by Farmer, [1] only a few successful examples on the synthesis of peptidomimetics based on rigid scaffolds such as cyclohexane and