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Solid-phase synthesis of dehydropeptide, AM-toxin II, using a novel selenyl linker by side-chain tethered strategy

✍ Scribed by Eiji Horikawa; Masato Kodaka; Yoshiaki Nakahara; Hiroaki Okuno; Kazuhiko Nakamura


Publisher
Elsevier Science
Year
2001
Tongue
French
Weight
91 KB
Volume
42
Category
Article
ISSN
0040-4039

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✦ Synopsis


The cyclic dehydrodepsipeptide, AM-toxin II, was efficiently synthesized by a solid-phase method using a novel selenyl linker. The cleavage from the resin with formation of a double bond is successfully achieved under mild oxidative conditions with TBHP.