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Solid-Phase Synthesis of Cyclic Lipopeptidotriazoles

✍ Scribed by Vilà, Sílvia; Camó, Cristina; Figueras, Eduard; Badosa, Esther; Montesinos, Emilio; Planas, Marta; Feliu, Lidia


Book ID
125854550
Publisher
John Wiley and Sons
Year
2014
Tongue
English
Weight
291 KB
Volume
2014
Category
Article
ISSN
1434-193X

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Cyclic peptides are excellent tools to investigate the functional and spatial requirements for ligands to bind to a given target. In this paper we report the synthesis of a library of cyclic hexapeptides, designed to be Selectin antagonists. Based on molecular modelling calculations, these peptides