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Solid-phase synthesis of combinatorial libraries based on enatiomerically pure (1S,2S,4R,5S)-4,5-dihydroxycyclohexan-1,2-dicarboxylic acid scaffolds

✍ Scribed by Daniela Arosio; Anna Bernardi; Donatella Dellavecchia; Fabrizio Micheli; Alessandra Pasquarello


Book ID
114019181
Publisher
Elsevier Science
Year
2002
Tongue
English
Weight
152 KB
Volume
57
Category
Article
ISSN
0014-827X

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## Abstract The homochiral 1,3‐dioxanes 8a–e with a 2‐bromophenyl substituent in position 2 and an electrophilic group in position 4 were stereo‐ and regioselectively prepared from the (__S__)‐malic acid derivatives 6a, 6b, 11, and 14. Attempts to prepare the tricycles 5a–c by connecting the 2‐phen