✦ LIBER ✦
Solid Phase Synthesis of 17α-E/Z-(X-Phenyl)-Vinyl Estradiols Using the Stille Coupling Reaction
✍ Scribed by Choon Young Lee; Robert N Hanson
- Book ID
- 104202489
- Publisher
- Elsevier Science
- Year
- 2000
- Tongue
- French
- Weight
- 131 KB
- Volume
- 56
- Category
- Article
- ISSN
- 0040-4020
No coin nor oath required. For personal study only.
✦ Synopsis
As a continuation of our program to develop probes for the hormone binding domain (HBD) of the estrogen receptor (ER), we designed a series of novel 17a-E/Z-(X-phenyl)-vinyl estradiols. Based upon our experience with solution chemistry we applied solid phase synthesis using carboxylated resins to synthesize the new compounds. The Stille coupling reaction permitted the introduction of a variety of functional groups and positional isomers on the terminal phenyl group. Subsequent cleavage from the resin generated a series of novel estradiol derivatives.