✦ LIBER ✦

Solid phase reduction of 99mTcO with zinc : A method for the preparation of difficult 99m complexes

✍ Scribed by C. Kremer; A. León; D. Gambino; S. Cartesio; C. Ures; E. Savio; E. Campos; E. Kremer

Book ID: 102372764
Publisher: John Wiley and Sons
Year: 1989
Tongue: French
Weight: 373 KB
Volume: 27
Category: Article
ISSN: 0022-2135
DOI: 10.1002/jlcr.2580271113

No coin nor oath required. For personal study only.

✦ Synopsis

SUMWRY

Two

groups of carnpounds: arninoacids (glutamic acid, g 1 ut ami ne, g 1 yci ne, 1 ysi ne) and arni nes (et hy 1 ened i am i ne, d iethy 1 enet r i amine, o-phenant rol i ne, o-phenylened i ami ne) have been labelled with oPnTc by means of a solid phase reduction using fine powdered zinc a5 reducing agent. In all. cases radiochemical purity in excess of 90% was obtained, with no evidence of colloid format ion.

Label 1 ing yields were variable depending on the ligand used.

The results show that the method presented allows to label with p 9 m T ~ some mctlecoles for which the use of conventional techniques is not feasible.

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