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Solid Lipid Nanoparticles Enhance the Delivery of the HIV Protease Inhibitor, Atazanavir, by a Human Brain Endothelial Cell Line

✍ Scribed by Niladri Chattopadhyay; Jason Zastre; Ho-Lun Wong; Xiao Yu Wu; Reina Bendayan

Book ID
106493456
Publisher
Springer US
Year
2008
Tongue
English
Weight
309 KB
Volume
25
Category
Article
ISSN
0724-8741

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## Abstract A major concern regarding the chronic administration of antiretroviral drugs is the potential for induction of drug efflux transporter expression (i.e., P‐glycoprotein, P‐gp) at tissue sites that can significantly affect drug distribution and treatment efficacy. Previous data have shown