2,4-Disubstituted 1-benzoyl-2,3-dihydro-1H-1,5-benzodiazepines were oxidized by m-chloroperbenzoic acid (MCPBA) to produce 1a, 3-disubstituted 4-benzoyl-1a,2,3,4-tetrahydro-oxazirino[2,3a][1,5]benzodiazepines, a novel tricyclic heterocyclic system. However, 2,4-disubstituted 2,3-dihydro-1H-1,5-benzo
Solid acid catalytic synthesis of 1,5-benzodiazepines: A highly improved protocol
β Scribed by Mahmood Tajbakhsh; Majid M. Heravi; Bagher Mohajerani; Amir N. Ahmadi
- Book ID
- 104056949
- Publisher
- Elsevier Science
- Year
- 2006
- Tongue
- English
- Weight
- 97 KB
- Volume
- 247
- Category
- Article
- ISSN
- 1381-1169
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2,3-Dihydro-1H-1,5-benzodiazepines are synthesized by the condensation of o-phenylendiamine and various ketones in the presence of a versatile solid superacid catalyst 'sulfated zirconia' under solvent free conditions.