## Abstract Oncogenic mutations in the __KRAS2__, __NRAS__, or __FLT3__ gene are detected in more than 50% of patients with de novo acute myeloid leukemia (AML). __RAS__ mutations are also prevalent in de novo myelodysplastic syndrome (MDS), especially chronic myelomonocytic leukemia and juvenile m
β¦ LIBER β¦
Sole abnormalities of chromosome 7 in myeloid malignancies: Spectrum, histopathologic correlates, and prognostic implications
β Scribed by Fareeda Taher Nazer Hussain; Edward P. Nguyen; Sania Raza; Ryan Knudson; Animesh Pardanani; Curtis A. Hanson; Daniel Van Dyke; Ayalew Tefferi
- Book ID
- 111994796
- Publisher
- John Wiley and Sons
- Year
- 2012
- Tongue
- English
- Weight
- 771 KB
- Volume
- 87
- Category
- Article
- ISSN
- 0361-8609
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## Abstract Southern blot hybridization studies were performed on 23 mesothelioma primary tumor specimens to detect chromosome 1β, 7β, and 22βspecific numerical changes, gene amplifications, and gene rearrangements. The molecular findings were compared with previous cytogenetic findings. No gene re