frequently several million base pairs and as, at a rough estimate, the average density of genes transcribed in a given tissue is only four per one million base pairs, the isolation of a disease gene would be facilitated by focussing efforts on expressed sequences. Specifically, identifying sequences
Software Trapping: A Strategy for Finding Genes in Large Genomic Regions
β Scribed by Alexander Kamb; Chunwei Wang; Alun Thomas; Bradley S. DeHoff; Franklin H. Norris; Katherine Richardson; Jasper Rine; Mark H. Skolnick; Paul R. Rosteck Jr.
- Publisher
- Elsevier Science
- Year
- 1995
- Tongue
- English
- Weight
- 414 KB
- Volume
- 28
- Category
- Article
- ISSN
- 0010-4809
No coin nor oath required. For personal study only.
π SIMILAR VOLUMES
## Abstract Homozygous deletions are instrumental in the detection and cloning of tumor suppressor genes. We report the isolation and characterization of 39 new singleβcopy probes saturating a submicroscopic homozygous deletion detected in the DNA of the small cell lung cancer (SCLC) cell line U202
Hidrotic ectodermal dysplasia (HED), Clouston syndrome (MIM No. 129500), is an autosomal dominant disorder affecting the skin and its derivatives. It is characterized by alopecia, dysplastic nails in hands and feet, and hyperkeratosis of the palms and soles. We have studied a large Indian pedigree (