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Sodium withdrawal contractures in developing and regenerating rat extensor digitorum longus muscles

✍ Scribed by Jean-Pierre Louboutin; Jacques Noireaud


Publisher
John Wiley and Sons
Year
1998
Tongue
English
Weight
75 KB
Volume
21
Category
Article
ISSN
0148-639X

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✦ Synopsis


During postnatal development of extensor digitorum longus (EDL) muscle, sodium withdrawal contractures were observed during the first 6 days after birth, and not after this time. In regenerating EDL muscles, zero-Na contractures were demonstrated: (1) 7 days after bupivacaine injection, but not 14 or 90 days after this injection; (2) 7, 14, and 90 days after autotransplantation; and (3) 7, 14, and 90 days after the intervention in sliced muscles. The present findings emphasize the role of the denervation in the development of zero-Na contractures in the regenerating muscles and suggest that a calcium-sodium exchange across the sarcolemma may appear in these muscles.


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Effects of external calcium on contracti
✍ Jean-Pierre Louboutin; ValΓ©rie Fichter-Gagnepain; Jacques Noireaud πŸ“‚ Article πŸ“… 1996 πŸ› John Wiley and Sons 🌐 English βš– 706 KB

Two types of nerve lesions were performed at birth in rat extensor digitorum longus muscle: sciatic nerve transection (group A) and sciatic nerve crush allowing further reinnervation (group 6). Contractile responses were then studied at different times after the denervation (7, 14, 30, and 60 days)