Sodium withdrawal contractures in developing and regenerating rat extensor digitorum longus muscles
β Scribed by Jean-Pierre Louboutin; Jacques Noireaud
- Publisher
- John Wiley and Sons
- Year
- 1998
- Tongue
- English
- Weight
- 75 KB
- Volume
- 21
- Category
- Article
- ISSN
- 0148-639X
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β¦ Synopsis
During postnatal development of extensor digitorum longus (EDL) muscle, sodium withdrawal contractures were observed during the first 6 days after birth, and not after this time. In regenerating EDL muscles, zero-Na contractures were demonstrated: (1) 7 days after bupivacaine injection, but not 14 or 90 days after this injection; (2) 7, 14, and 90 days after autotransplantation; and (3) 7, 14, and 90 days after the intervention in sliced muscles. The present findings emphasize the role of the denervation in the development of zero-Na contractures in the regenerating muscles and suggest that a calcium-sodium exchange across the sarcolemma may appear in these muscles.
π SIMILAR VOLUMES
Two types of nerve lesions were performed at birth in rat extensor digitorum longus muscle: sciatic nerve transection (group A) and sciatic nerve crush allowing further reinnervation (group 6). Contractile responses were then studied at different times after the denervation (7, 14, 30, and 60 days)