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Sodium Selenite-Induced Apoptosis Mediated by ROS Attack in Human Osteosarcoma U2OS Cells

✍ Scribed by Xiao-jia Chen; Fei-die Duan; Hui-hua Zhang; Yi Xiong; Jin Wang

Book ID: 107567370
Publisher: Humana Press Inc
Year: 2011
Tongue: English
Weight: 570 KB
Volume: 145
Category: Article
ISSN: 0163-4984
DOI: 10.1007/s12011-011-9154-2

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The mechanisms involved in the anti-carcinogenic activity of selenium remain to be elucidated. In the present study, we examined sodium selenite-induced oxidative stress and apoptosis in a human hepatoma cell line (HepG 2 ). Sodium selenite (10 M) exerted clear cytotoxic effect, as shown by the sign