✦ LIBER ✦

Sodium renal imaging in mice at high magnetic fields

✍ Scribed by Thomas Neuberger; Vikas Gulani; Andrew Webb

Book ID: 102533862
Publisher: John Wiley and Sons
Year: 2007
Tongue: English
Weight: 282 KB
Volume: 58
Category: Article
ISSN: 0740-3194
DOI: 10.1002/mrm.21402

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✦ Synopsis

Abstract

This work presents the first sodium MRI functional renal study on a mouse model. The tissue sodium concentration was monitored during induced diuresis with furosemide. By using density‐weighted chemical shift imaging (DWCSI) at high field strength a temporal resolution of less than 5 min for three dimensional (3D) data sets with high spatial resolution was achieved. A maximum increase of 20% in the cortex and a decrease of 45% of the original signal strength in the medulla were observed. These findings correspond well with experiments conducted on much larger rodent models. Magn Reson Med 58:1067–1071, 2007. © 2007 Wiley‐Liss, Inc.

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