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Sodium maleopimaric acid as pseudostationary phase for chiral separations of amino acid derivatives by capillary micellar electrokinetic chromatography

✍ Scribed by Hengshan Wang; Shulin Zhao; Min He; Zhicai Zhao; Yingming Pan; Qian Liang

Publisher
John Wiley and Sons
Year
2007
Tongue
English
Weight
596 KB
Volume
30
Category
Article
ISSN
1615-9306

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✦ Synopsis

Abstract

A new type of chiral surfactant, sodium maleopimaric acid (SMA), was synthesized, and employed for the enantioselective micellar electrokinetic chromatographic (MEKC) separation of amino acid enantiomers derivatized with naphthalene‐2,3‐dicarboxaldehyde (NDA‐D/L‐AAs). The effect of the surfactant concentration, type and concentration of the BGE, and buffer pH on the resolution was studied, and optimized conditions were used to evaluate the ability of this new surfactant to perform chiral separations toward NDA‐D/L‐AAs by MEKC. Enantiomeric separations of NDA‐D/L‐AAs were achieved with a running buffer consisting of 100 mM borate (pH 9.5) and 20 mM SMA in a 58.5 cm length×50 μm id capillary. Under the conditions selected, two pairs of tested amino acid enantiomers including NDA‐D/L‐trptophan (Trp) and NDA‐D/L‐kynurenine (Kyn) were resolved.

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