Sodium magnetic resonance imaging of proteoglycan depletion in an in vivo model of osteoarthritis1
β Scribed by Wheaton, Andrew J; Borthakur, Arijitt; Dodge, George R; Kneeland, J.Bruce; Schumacher, H.Ralph; Reddy, Ravinder
- Book ID
- 122762130
- Publisher
- Elsevier Science
- Year
- 2004
- Tongue
- English
- Weight
- 214 KB
- Volume
- 11
- Category
- Article
- ISSN
- 1076-6332
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Sodium magnetic resonance imaging of the human body in vivo has been tried and its clinical application is considered. A short T2 imaging algorithm with total volume excitation and a specialized RF coil focused to the region of interest have been adopted to improve the signal-to-noise ratio. Using a
## Abstract The purpose of this work is to demonstrate the feasibility of __T__~1Ο~βweighted magnetic resonance imaging (MRI) to quantitatively measure changes in proteoglycan content in cartilage. The __T__~1Ο~ MRI technique was implemented in an in vivo porcine animal model with rapidly induced c