✦ LIBER ✦
Sodium borohydride in dimethyl sulfoxide or sulfolane. Convenient systems for selective reductions of primary, secondary and certain tertiary halides and tosylates
✍ Scribed by Robert O. Hutchins; David Hoke; Joseph Keogh; David Koharski
- Book ID
- 104239756
- Publisher
- Elsevier Science
- Year
- 1969
- Tongue
- French
- Weight
- 191 KB
- Volume
- 10
- Category
- Article
- ISSN
- 0040-4039
No coin nor oath required. For personal study only.
✦ Synopsis
The use of various metal hydrides as selective reducing agents has attracted a considerable amount of interest in recent years (2). It occurred to us that one unexplored possibility in this area might be to employ the relatively mild reducing agent sodium borohydride in SNP rate enhancing, polar, aprotic solvents to selectively displace halogens and other good leaving groups with hydrogen without affecting other reducible functional groups.