SOCS3 Exerts Its Inhibitory Function on Interleukin-6 Signal Transduction through the SHP2 Recruitment Site of gp130

✍ Scribed by Schmitz, J.

• Book ID: 123610442
• Publisher: The American Society for Biochemistry and Molecular Biology
• Year: 2000
• Tongue: English
• Weight: 906 KB
• Volume: 275
• Category: Article
• ISSN: 0021-9258
• DOI: 10.1074/jbc.275.17.12848

✦ Synopsis

1

The abbreviations used are: IL, interleukin; Jak, Janus kinase; STAT, signal transducer and activator of transcription; SHP2, SH2containing protein-tyrosine phosphatase 2; SOCS, suppressor of cytokine signaling; SH2, Src homology domain 2; GST, glutathione Stransferase; APP, acute phase protein; CIS, cytokine-inducible SH2 protein; MAPK, mitogen-activated protein kinase; PIAS, protein inhibitor of activated STATS.