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SOCS1/JAB Is a Negative Regulator of LPS-Induced Macrophage Activation

✍ Scribed by Ichiko Kinjyo; Toshikatsu Hanada; Kyoko Inagaki-Ohara; Hiroyuki Mori; Daisuke Aki; Masanobu Ohishi; Hiroki Yoshida; Masato Kubo; Akihiko Yoshimura


Book ID
117723289
Publisher
Elsevier Science
Year
2002
Tongue
English
Weight
502 KB
Volume
17
Category
Article
ISSN
1074-7613

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Several cytokines have previously been shown to prime macrophages for enhanced release of oxygen radicals in response to subsequent stimulation. We now demonstrate that the presence of the macrophage-specific colony stimulating factor-1 (CSF-1) inhibits the priming of murine macrophages by a variety