Like the United States, Russia is a large industrialized nation with high violence rates. Although its overall homicide rate is among the highest in the world, however, local rates of crime vary widely. Similarly, the level of social support provided by the state varies throughout Russia due to former Soviet policies, the differential pace of political and economic change, and the level of development. Relying upon recent criminological literature on social support theory, this study tested the hypotheses that areas with higher levels of social support will have lower homicide rates and that the effects of negative socioeconomic change on homicide rates will be moderated by levels of social support. Utilizing data from Russian regions (n = 78) and controlling for other structural covariates, negative binomial regression was employed to estimate the effects of social support on regional homicide rates. As expected, negative socioeconomic change was associated with higher homicide rates, but the results provided no support for direct or conditioning effects of social support on homicide. The findings are discussed in the context of Russia-specific conditions and of the meaning of these findings for recent research on social support and crime.