Social selection in human populations: Protected polymorphism of deleterious alleles with incomplete penetrance
✍ Scribed by Dr. Shozo Yokoyama; James F. Crow
- Publisher
- John Wiley and Sons
- Year
- 1987
- Tongue
- English
- Weight
- 442 KB
- Volume
- 4
- Category
- Article
- ISSN
- 0741-0395
No coin nor oath required. For personal study only.
✦ Synopsis
Population dynamics of two alleles, A, and A2, at a locus under social selection have been studied by considering incomplete penetrance of the three genotypes. A social selection model is constructed by assuming that the fitness of an individual is determined by his or her own phenotype as well as parental phenotypes. For both multiplicative and additive fitness models, sufficient conditions for a protected polymorphism depend on the reduced fitness of affected individuals (y), the reduced fitness of all individuals resulting from affected parents (p), and the penetrance probabilities, f , , f2, andf3, for the three genotypes, AlA,, A I A ~, and A2A2. These conditions reduce to two biologically important cases: l ) f i < f2 > f 3 and /3 < -y/(ly) and 2)fl > fi < A and /3 > -y/(ly), and the most common form of the equilibrium frequency of the allele A2 is given by (fl -fZ)/(fl -2f2 + f3).