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SN2 reactions of a carbon nucleophile with N-aryl-O-pivaloylhydroxylamines: a model for in vivo reactions of carcinogenic metabolites of aromatic amines

✍ Scribed by Novak, Michael; Martin, Kristy A.; Heinrich, Julie L.


Book ID
126126655
Publisher
American Chemical Society
Year
1989
Tongue
English
Weight
230 KB
Volume
54
Category
Article
ISSN
0022-3263

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Tbe model reaction of 5 with 6 to give 7 and 8 (>90%) follows the SN~ mechankm. From this result and from product studies it is concluded that the reactions of the ultimate carcinogen 1 with 6 and deoxy8uanosine (dG) (and hence of other ultimate carcino8ens of aromatic amines with biot.mckophiles) f