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SN2′ Alkylation of Chiral Allylic Cyanohydrin O-Phosphates with Organocuprates.

✍ Scribed by Alejandro Baeza; Carmen Najera; Jose M. Sansano


Publisher
John Wiley and Sons
Year
2007
Weight
37 KB
Volume
38
Category
Article
ISSN
0931-7597

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SN2′ Alkylation of Chiral Allylic Cyanoh
✍ Alejandro Baeza; Carmen Nájera; José M. Sansano 📂 Article 📅 2007 🏛 John Wiley and Sons 🌐 English ⚖ 213 KB

## Abstract Enantiomerically enriched cyanohydrin __O__‐phosphates, prepared by enantioselective cyanophosphorylation of α,β‐unsaturated aldehydes, react regioselectively at the γ‐position with organocuprates derived from alkyl Grignard reagents and CuCN to afford chiral γ‐alkyl‐substituted α,β‐uns