Smurf1 ubiquitin ligase targets Kruppel-like factor KLF2 for ubiquitination and degradation in human lung cancer H1299 cells

Degradation of insulin-like growth facto

Degradation of insulin-like growth factor-I receptor occurs via ubiquitin-proteasome pathway in human lung cancer cells

✍ Stephana Carelli; Anna Maria Di Giulio; Simona Paratore; Silvano Bosari; Alfredo 📂 Article 📅 2006 🏛 John Wiley and Sons 🌐 English ⚖ 432 KB 👁 1 views

## Abstract Insulin‐like growth factor‐I receptor (IGF‐IR) is often overexpressed in malignant tumors, and is involved in the establishment and maintenance of malignant phenotypes. Tyrosine kinase receptor endocytosis is commonly triggered by ligand binding and occurs via clathrin‐coated vescicles