Smoking-related dna adducts in human gastric cancers

✍ Scribed by G. W. Dyke; J. L. Craven; R. Hall; R. C. Garner

• Book ID: 102866699
• Publisher: John Wiley and Sons
• Year: 1992
• Tongue: French
• Weight: 560 KB
• Volume: 52
• Category: Article
• ISSN: 0020-7136
• DOI: 10.1002/ijc.2910520602

✦ Synopsis

DNA was extracted from the tumour tissue of 26 patients (18 smokers, 8 non-smokers) undergoing surgery for gastric cancer, and analyzed for the presence of DNA adducts by the 32P-postlabelling method. Adducts were detected in all samples tested, and adduct levels ranged from 2 adducts/ lo* nucleotides to 60 adduct4 lo8 nucleotides. In male subjects, adduct levels were significantly greater in the DNA of smokers than in that of non-smokers. These results support epidemiological data suggesting that smoking is a risk factor for gastric cancer.