Smoking is associated with a decrease of
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Andrew C. Povey; Paul O'Donnell; Phil Barber; Mandy Watson; Geoffrey P. Margison
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Article
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2006
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John Wiley and Sons
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French
β 115 KB
## Abstract __O__^6^βalkylguanineβDNA alkyltransferase (MGMT) represents the first line of defense against the toxic, mutagenic and carcinogenic effects of __O__^6^βalkylguanine adducts in DNA. These adducts mediate the biological activity from a series of alkylating agents, such as the tobaccoβspe