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Smoking is associated with increased telomerase activity in short-term cultures of human bronchial epithelial cells

✍ Scribed by Hyeon Woo Yim; Robbert J.C. Slebos; Scott H. Randell; David M. Umbach; Alden M. Parsons; M. Patricia Rivera; Frank C. Detterbeck; Jack A. Taylor


Book ID
116334149
Publisher
Elsevier Science
Year
2007
Tongue
English
Weight
180 KB
Volume
246
Category
Article
ISSN
0304-3835

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✍ Andrew C. Povey; Paul O'Donnell; Phil Barber; Mandy Watson; Geoffrey P. Margison πŸ“‚ Article πŸ“… 2006 πŸ› John Wiley and Sons 🌐 French βš– 115 KB

## Abstract __O__^6^‐alkylguanine‐DNA alkyltransferase (MGMT) represents the first line of defense against the toxic, mutagenic and carcinogenic effects of __O__^6^‐alkylguanine adducts in DNA. These adducts mediate the biological activity from a series of alkylating agents, such as the tobacco‐spe