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Smoking, citrullination and genetic variability in the immunopathogenesis of rheumatoid arthritis

✍ Scribed by Lars Klareskog; Vivianne Malmström; Karin Lundberg; Leonid Padyukov; Lars Alfredsson

Book ID
116885669
Publisher
Elsevier Science
Year
2011
Tongue
English
Weight
406 KB
Volume
23
Category
Article
ISSN
1044-5323

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✍ Erik R. Vossenaar; Suzanne Nijenhuis; Monique M. A. Helsen; Annemarie van der He 📂 Article 📅 2003 🏛 John Wiley and Sons 🌐 English ⚖ 452 KB 👁 2 views

## Abstract ## Objective Antibodies directed to citrulline‐containing proteins are highly specific for rheumatoid arthritis (RA) and can be detected in up to 80% of patients with RA. Citrulline is a nonstandard amino acid that can be incorporated into proteins only by posttranslational modificatio