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Smoking and the risk of breast cancer among carriers of BRCA mutations

✍ Scribed by Parviz Ghadirian; Jan Lubinski; Henry Lynch; Susan L. Neuhausen; Barbara Weber; Claudine Isaacs; Ruth-Gershoni Baruch; Susan Randall; Peter Ainsworth; Eitan Freidman; Douglas Horsman; Patricia Tonin; William D. Foulkes; Nadine Tung; Ping Sun; Steven A. Narod

Publisher
John Wiley and Sons
Year
2004
Tongue
French
Weight
68 KB
Volume
110
Category
Article
ISSN
0020-7136

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✦ Synopsis

Abstract

The effect of cigarette smoking on the risk of breast cancer is controversial, although most studies show little or no effect. It has been suggested that smoking may reduce the risk of developing hereditary breast cancer. We completed a case‐control study on 1,097 women with breast cancer who were BRCA1 or BRCA2 mutation carriers and 1,097 age‐matched controls with a mutation in the same gene but without breast cancer. There were no statistically significant differences between the cases and controls in terms of the number of current and ex‐smokers (41.2% and 40.4%, respectively) or the age at smoking commencement (18.2 years and 18.5 years, respectively). There were no statistically significant differences between cases and controls regarding beginning smoking within 5 years of menarche (OR = 1.03; 95% CI 0.83 to l.28) or before the first pregnancy (OR = 1.09; 95% CI = 0.90 to 1.33). In conclusion, contrary to our previous report, smoking does not appear to be a risk factor for breast cancer among carriers of BRCA mutations. © 2004 Wiley‐Liss, Inc.

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