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Small sample properties of some parametric bioassay estimators of the LD90

โœ Scribed by Richard M. Engeman; David L. Otis; William E. Dusenberry

Publisher
Elsevier Science
Year
1986
Tongue
English
Weight
492 KB
Volume
19
Category
Article
ISSN
0010-4809

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โœฆ Synopsis

Bioassay experiments are frequently conducted with small sample sizes, but the literature offers little comparative information for small sample sizes among the analytical procedures. A computer simulation study was performed to compare several traditional analytical procedures for estimating the LD,. These estimation procedures include probit analysis with maximum likelihood estimation, logit analysis with maximum likelihood, and minimum x2 estimation methods. The simulation results indicate the conditions under which each analytical method appears most useful. Recommendations are tentatively made for minimally adequate designs for bioassay studies where an LDw is to be estimated.

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