Small nuclear RNP tightly bound to chromatin is possibly involved in hormonal regulation of gene expression
✍ Scribed by I. M. Konstantinova; V. A. Kulitchkova; O. A. Petukhova; L. V. Turoverova; I. V. Volkova; V. I. Vorob'ev
- Publisher
- Springer
- Year
- 1990
- Tongue
- English
- Weight
- 119 KB
- Volume
- 14
- Category
- Article
- ISSN
- 0301-4851
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✦ Synopsis
it was shown earlier that the specific small RNP (=RNP) can be extracted from rat liver chromatin together with histones (Konstantinova et at., 1984). Moreover, fractionation of cortisone-activated rat liver chromatin on transcriptionally active and inactive fractions (Turoverova and Vorob'ev, 1980) revealed that this RNP is bound predominantely in the active fraction of chromatin. The radioactive hydrocortisone or dexamethasone after in vivo injection is bound mainLy to this smart RNP (Turoverova et at., 1987), so the tatter can be regarded as the nuclear acceptor of hormone.