Small molecule tolfenamic acid inhibits PC-3 cell proliferation and invasion in vitro, and tumor growth in orthotopic mouse model for prostate cancer

Inhibition of cell proliferation, invasi

Inhibition of cell proliferation, invasion, tumor growth and metastasis by an oral non-antimicrobial tetracycline analog (COL-3) in a metastatic prostate cancer model

✍ Bal L. Lokeshwar; Marie G. Selzer; Bao-Qian Zhu; Norman L. Block; Lorne M. Golub 📂 Article 📅 2002 🏛 John Wiley and Sons 🌐 French ⚖ 460 KB

## Abstract Antibiotic forms of tetracycline exhibit antitumor activity in some tumor models. However, their low __in vivo__ efficacy and associated morbidity limit their long‐term application in cancer therapy. This report appraises the efficacy of doxycycline (DC) and non‐antimicrobial, chemicall