Small-Molecule Regulators of Human Stem Cell Self-Renewal

Dorsomorphin Promotes Human Embryonic St

Dorsomorphin Promotes Human Embryonic Stem Cell Self-Renewal

✍ Dr. Rodolfo Gonzalez; Dr. Jae Wook Lee; Prof. Evan Y. Snyder; Prof. Peter G. Sch 📂 Article 📅 2011 🏛 John Wiley and Sons 🌐 English ⚖ 989 KB

Human embryonic stem cells (hESCs), derived from the inner cell mass (ICM) of the blastocyst, have the capacity for longterm undifferentiated growth in culture and the theoretical potential to differentiate into all somatic cell types. [1] These hESCs offer not only a model system for human developm

Dorsomorphin Promotes Human Embryonic St

Dorsomorphin Promotes Human Embryonic Stem Cell Self-Renewal

✍ Dr. Rodolfo Gonzalez; Dr. Jae Wook Lee; Prof. Evan Y. Snyder; Prof. Peter G. Sch 📂 Article 📅 2011 🏛 John Wiley and Sons 🌐 English ⚖ 978 KB

Human embryonic stem cells (hESCs), derived from the inner cell mass (ICM) of the blastocyst, have the capacity for longterm undifferentiated growth in culture and the theoretical potential to differentiate into all somatic cell types. [1] These hESCs offer not only a model system for human developm

Hydrogels as artificial matrices for hum

Hydrogels as artificial matrices for human embryonic stem cell self-renewal

✍ Ying J. Li; Eugene H. Chung; Ryan T. Rodriguez; Meri T. Firpo; Kevin E. Healy 📂 Article 📅 2006 🏛 John Wiley and Sons 🌐 English ⚖ 304 KB

## Abstract Human embryonic stem cells (hESCs) have the potential to differentiate into all cell types in the body and hold great promise for regenerative medicine; however, large‐scale expansion of undifferentiated hESCs remains a major challenge. Self‐renewal of hESCs requires culturing these cel

Epigenetic regulation of self-renewal an

Epigenetic regulation of self-renewal and fate determination in neural stem cells

✍ Iqbal Mohamed Ariff; Arinjay Mitra; Anirban Basu 📂 Article 📅 2011 🏛 John Wiley and Sons 🌐 English ⚖ 232 KB

## Abstract Differentiation and self‐renewal are two primary properties that characterize stem cells. Differentiation of neural stem/precursor cells (NSPCs) gives rise to multiple neural lineages, including neurons, astrocytes, and oligodendrocytes. Self‐renewal, by definition, signifies the progre

Insulin receptor substrate (IRS)-1 regul

Insulin receptor substrate (IRS)-1 regulates murine embryonic stem (mES) cells self-renewal

✍ Raphael Rubin; Alla Arzumanyan; Angela Rachele Soliera; Brian Ross; Francesca Pe 📂 Article 📅 2007 🏛 John Wiley and Sons 🌐 English ⚖ 441 KB

## Abstract Mouse embryonic stem (mES) cells are pluripotent cells that can be propagated in vitro with leukemia inhibitory factor (LIF) and serum. Intracellular signaling by LIF is principally mediated by activation of STAT‐3, although additional pathways for self‐renewal have been described. Here

Generation of human induced pluripotent

Generation of human induced pluripotent stem cells from liver progenitor cells by only small molecules

✍ Moriguchi Hisashi; Chung Raymond T.; Mihara Makoto; Sato Chifumi 📂 Article 📅 2010 🏛 John Wiley and Sons 🌐 English ⚖ 277 KB

The team of Liu et al. generated endoderm-derived human induced pluripotent stem (iPS) cells from primary hepatocytes. 1 However, they generated human iPS cells by using viral transgenes. 1 Clinical applications of human iPS cells require avoiding viral transgenes. On the other hand, the reprogrammi