Small Molecule — Protein Interactions

✍ Scribed by J. Reinhard-Rupp, G. Wess (auth.), H. Waldmann, M. Koppitz (eds.)

Publisher: Springer-Verlag Berlin Heidelberg
Year: 2003
Tongue: English
Leaves: 236
Series: Ernst Schering Research Foundation Workshop 42
Edition: 1
Category: Library

No coin nor oath required. For personal study only.

✦ Synopsis

Based on the international workshop on 'Small Molecule - Protein Interactions' held in Berlin, April 24-26, 2002, researchers from industry and academic laboratories describe novel and efficient ways selecting promising new drug targets and developing small molecule inhibitors against them. The structure of the book corresponds to the different aspects of the drug discovery process. All chapters are written by leading experts in the field, who present and discuss the most recent state-of-the-art tools and techniques for the development of novel drugs. The value of the book lies in surveying and summarizing the approaches taken by different companies and institutions giving the reader a balanced view on the use of the latest techniques on the one hand and experience-based assistance in selecting appropriate tools for their own work on the other hand.

✦ Table of Contents

Front Matter....Pages I-XV
Drug Discovery Opportunities....Pages 1-10
Target Analysis: A Priori Assessment of Druggability....Pages 11-17
Drug Discovery at Signaling Interfaces....Pages 19-27
Chemical Genomics of Orphan Nuclear Receptors....Pages 29-42
High-Throughput X-Ray Techniques and Drug Discovery....Pages 43-58
NMR in Medicinal Chemistry....Pages 59-85
Creating Knowledge from High-Throughput Screening Data....Pages 87-101
From Structure to Recognition Principles: Mining in Crystal Data as a Prerequisite for Drug Design....Pages 103-126
Practical Database Screening with Docking Tools....Pages 127-151
De Novo Design Methods....Pages 153-166
From Protein Domains to Drug Candidates — Natural Products as Guiding Principles in Compound Library Design and Synthesis....Pages 167-188
Discovery of New MCRs, Chemical Evolution and Lead Optimization....Pages 189-199
The Impact of Combinatorial Chemistry on Drug Discovery....Pages 201-220
Back Matter....Pages 221-228

✦ Subjects

Biomedicine general; Medical Biochemistry; Pharmacology/Toxicology; Molecular Medicine

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