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Small-Molecule Inhibitors of the ERK Signaling Pathway: Towards Novel Anticancer Therapeutics

✍ Scribed by Jeremy L. Yap; Dr. Shilpa Worlikar; Prof. Dr. Alexander D. MacKerell Jr.; Prof. Dr. Paul Shapiro; Prof. Dr. Steven Fletcher


Publisher
John Wiley and Sons
Year
2010
Tongue
English
Weight
633 KB
Volume
6
Category
Article
ISSN
1860-7179

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## Abstract The Flt3 receptor tyrosine kinase is a critical mediator in the pathogenesis of acute myeloid leukaemia (AML). Flt3‐activating mutations have been associated with poor prognosis and decreased overall survival of AML patients, thus Flt3 constitutes an ideal target for drug treatment of s