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Small-molecule androgen receptor downregulators as an approach to treatment of advanced prostate cancer

โœ Scribed by Robert H. Bradbury; Neil J. Hales; Alfred A. Rabow; Graeme E. Walker; David G. Acton; David M. Andrews; Peter Ballard; Nigel A.N. Brooks; Nicola Colclough; Alan Girdwood; Urs J. Hancox; Owen Jones; David Jude; Sarah A. Loddick; Andrew A. Mortlock


Book ID
113495931
Publisher
Elsevier Science
Year
2011
Tongue
English
Weight
449 KB
Volume
21
Category
Article
ISSN
0960-894X

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โœ Liang Schweizer; Cheryl A Rizzo; Thomas E Spires; J Suso Platero; Qiuyan Wu; Tai ๐Ÿ“‚ Article ๐Ÿ“… 2008 ๐Ÿ› BioMed Central ๐ŸŒ English โš– 816 KB

## Background A crucial event in Prostate Cancer progression is the conversion from a hormone-sensitive to a hormone-refractory disease state. Correlating with this transition, androgen receptor (AR) amplification and mutations are often observed in patients failing hormonal ablation therapies. ฮฒ-C