✦ LIBER ✦

Small Libraries of Polymer-Supported Amino Alcohols: An Application to the Enantioselective Reduction of Acetophenone by LAH

✍ Scribed by B. Altava; M. I. Burguete; E. García-Verdugo; S. V. Luis; O. Pozo; Rosa V. Salvador

Publisher: John Wiley and Sons
Year: 1999
Tongue: English
Weight: 137 KB
Volume: 1999
Category: Article
ISSN: 1434-193X
DOI: 10.1002/(sici)1099-0690(199909)1999:9<2263::aid-ejoc2263>3.0.co;2-2

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✦ Synopsis

Starting from simple amino acid esters and Merrifield resins, reagents are able to reduce acetophenone to 1-phenylethanol. Enantioselectivity is observed when the steric a small library of polymer-bound chiral-β-amino alcohols can be prepared. By reaction with LiALH 4 the corresponding hindrance in the chiral fragment is increased. Best results are obtained for the supported derivative of α,α-diphenyl chiral reducing agents are obtained, having structural variations at both the α and β positions. All supported phenylalaninol.