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Small interfering RNA (siRNA) targetted to Smad3 inhibits transforming growth factor-β signaling

✍ Scribed by Seon-yong Yeom; Dooil Jeoung; Kwon-Soo Ha; Pyeung-Hyeun Kim


Book ID
111573521
Publisher
Springer Netherlands
Year
2004
Tongue
English
Weight
278 KB
Volume
26
Category
Article
ISSN
0141-5492

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Transforming growth factor-␤ (TGF-␤) is a potent inhibitor of cell proliferation. This study investigated whether overexpression of Smad7, which blocks TGF-␤-induced activation of Smad2/3, could prevent the suppression of regeneration of small-for-size liver grafts. Rats were intravenously given ade