One hundred and forty thousand patients in the United States will develop lung cancer annually. About one half of these will have disease confined to the thorax with no clinical evidence of dissemination (Figure 1). A relatively high proportion of these patients will actually have disease that can b
Small-cell lung cancer: An overview of issues in therapy
β Scribed by Robert E. Wittes
- Publisher
- John Wiley and Sons
- Year
- 1993
- Tongue
- English
- Weight
- 917 KB
- Volume
- 9
- Category
- Article
- ISSN
- 8756-0437
No coin nor oath required. For personal study only.
β¦ Synopsis
As one of the few chemo-and radiosensitive neoplasms among the common epithelial solid tumors of adults, small-cell lung cancer has long tantalized clinical investigators. Although for the last 15-20 years therapy has yielded high remission rates, including substantial complete remission rates, results have not improved very much over nearly two decades of intensive therapeutic research, and long-term diseasefree survival remains an elusive goal for the large majority of patients. At this point the number of promising untested hypotheses in therapy is quite small, and major advances will probably have to await either the serendipitous discovery of much more active drugs than we now possess, or else the purposeful development of new approaches based on insights into the nature of the transformed state and the biology of SCLC itself. @ 1993 Wiley-Liss, Inc.
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