## Small bowel transplantation Over 30 years ago Richard Lillehei and colleagues from Minneapolis carried out experiments demonstrating that, from a technical point of view, transplantation of the gut was feasible'. However, it rapidly became clear that compared with other forms of organ grafting
Small bowel transplantation
β Scribed by Dr. Peter Schroeder; Matthias Gundlach; Eva Schweizer; Eberhard Deltz
- Publisher
- John Wiley and Sons
- Year
- 1990
- Tongue
- English
- Weight
- 375 KB
- Volume
- 11
- Category
- Article
- ISSN
- 0738-1085
No coin nor oath required. For personal study only.
β¦ Synopsis
Abstract
Small intestinal transplantation has had several clinical attempts based on extensive experimental work during the past two decades. Several models, such as auxiliary (heterotopic) or orthotopic models, have been developed in regard to problems with graft immunology and function. The question of mesentericβportal or mesentericβcaval graft drainage was raised, and the answer seems to be open. Concerning lipid absorption, interest was directed to the reconstitution of lymphatic vessels, because orally administered cyclosporine A is absorbed by the lipid mechanism. Carbohydrate digestion and absorption are used for determination of graft function and for monitoring graft rejection. This article summarizes these problems and deals with the surgical procedure of small bowel transplantation in the rat.
π SIMILAR VOLUMES
Small bowel transplantation is emerging as an alternative treatment for end-stage intestinal failure. To date, immunological and technical problems are still hampering clinical success. Functional experimental small bowel transplantation models have traditionally been plagued with a high technical c