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Smad7 mediates inhibition of Saos2 osteosarcoma cell differentiation by NFκB

✍ Scribed by Roman A. Eliseev; Edward M. Schwarz; Michael J. Zuscik; Regis J. O'Keefe; Hicham Drissi; Randy N. Rosier

Book ID: 113955491
Publisher: Elsevier Science
Year: 2006
Tongue: English
Weight: 514 KB
Volume: 312
Category: Article
ISSN: 0014-4827
DOI: 10.1016/j.yexcr.2005.09.016

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## Abstract To elucidate the possible effect of NFκB on radioresistance, we used the osteosarcoma cell line Saos2, stably expressing the NFκB constitutive inhibitor, mIκB (Saos2‐mIκB) or stably transfected with the empty vector (Saos2‐EV). Ionizing radiation induced “intrinsic” apoptosis in Saos2‐m