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Smad7 induces hepatic metastasis in colorectal cancer

✍ Scribed by Halder, S K; Rachakonda, G; Deane, N G; Datta, P K

Book ID: 109999656
Publisher: Nature Publishing Group
Year: 2008
Tongue: English
Weight: 610 KB
Volume: 99
Category: Article
ISSN: 0007-0920
DOI: 10.1038/sj.bjc.6604562

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## Abstract Chromosomal region 18q21 is frequently deleted in colorectal cancer (CRC) and is associated with poor prognosis. Potential tumor suppressor mechanisms altered by 18q21 deletion include mediation of TGFβ signaling by SMADs. Following the definition of __SMAD4__ deletion as a negative pre