𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Smad3 is key to TGF-β-mediated epithelial-to-mesenchymal transition, fibrosis, tumor suppression and metastasis

✍ Scribed by Anita B. Roberts; Fang Tian; Stacey DaCosta Byfield; Christina Stuelten; Akira Ooshima; Shizuya Saika; Kathleen C. Flanders

Book ID
116401003
Publisher
Elsevier Science
Year
2006
Tongue
English
Weight
325 KB
Volume
17
Category
Article
ISSN
1359-6101

No coin nor oath required. For personal study only.

📜 SIMILAR VOLUMES

Side population of pancreatic cancer cel
Side population of pancreatic cancer cells predominates in TGF-β-mediated epithelial to mesenchymal transition and invasion
✍ Ayano Kabashima; Hajime Higuchi; Hiromasa Takaishi; Yumi Matsuzaki; Sadafumi Suz 📂 Article 📅 2009 🏛 John Wiley and Sons 🌐 French ⚖ 424 KB

## Abstract We report here side population (SP) cells, a cancer stem cell enriched fraction from pancreatic cancer cell line, have enormous superior potential of the epithelial to mesenchymal transition (EMT), invasion, and metastasis. In an isolated SP cell culture, the cells rapidly expressed and

Constitutively active MEK1 is sufficient
Constitutively active MEK1 is sufficient to induce epithelial-to-mesenchymal transition in intestinal epithelial cells and to promote tumor invasion and metastasis
✍ Étienne Lemieux; Sébastien Bergeron; Véronique Durand; Claude Asselin; Caroline 📂 Article 📅 2009 🏛 John Wiley and Sons 🌐 French ⚖ 495 KB 👁 1 views

## Abstract Constitutive activation of the MAP kinase kinase MEK1 induces oncogenic transformation in intestinal epithelial cells. Loss of cell–cell adhesion followed by the dissociation of epithelial structures is a prerequisite for increased cell motility and tumor invasion. This phenotypic switc